Gene information
Official symbol AGTR1
Official full name angiotensin II receptor type 1
Gene type protein-coding gene
Chromosome3q24
Alias symbolAT1; AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B
Previous symbolAGTR1B
Gene familyAngiotensin receptors
Resources
Entrez Gene 185
HGNC HGNC:336
Ensembl ENSG00000144891
Vega OTTHUMG00000159503
UCSC uc003ewj.4
GO terms: 84 records
GO Description Category LogP Number of genes Detail
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001822 kidney development GO Biological Processes -16.2664835 49 More
GO:0002016 regulation of blood volume by renin-angiotensin GO Biological Processes -9.66344956 6 More
GO:0002034 maintenance of blood vessel diameter homeostasis by renin-angiotensin GO Biological Processes -4.82387082 4 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003014 renal system process GO Biological Processes -10.4348518 24 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal GO Biological Processes -12.8867024 12 More
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure GO Biological Processes -9.64792348 8 More
GO:0003072 renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure GO Biological Processes -4.82387082 4 More
GO:0003073 regulation of systemic arterial blood pressure GO Biological Processes -22.2238525 34 More
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin GO Biological Processes -6.90547690 6 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO Biological Processes -11.6592522 24 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0007264 small GTPase mediated signal transduction GO Biological Processes -2.76738893 22 More
GO:0007265 Ras protein signal transduction GO Biological Processes -1.87357952 15 More
GO:0007266 Rho protein signal transduction GO Biological Processes -1.86130079 7 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0010517 regulation of phospholipase activity GO Biological Processes -7.06832255 9 More
GO:0010518 positive regulation of phospholipase activity GO Biological Processes -7.78358420 9 More
GO:0010743 regulation of macrophage derived foam cell differentiation GO Biological Processes -20.3455172 15 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0010872 regulation of cholesterol esterification GO Biological Processes -10.0035192 7 More
GO:0010873 positive regulation of cholesterol esterification GO Biological Processes -7.55914528 5 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019218 regulation of steroid metabolic process GO Biological Processes -14.2494824 17 More
GO:0019229 regulation of vasoconstriction GO Biological Processes -25.9471687 22 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0033860 regulation of NAD(P)H oxidase activity GO Biological Processes -5.22169943 4 More
GO:0033864 positive regulation of NAD(P)H oxidase activity GO Biological Processes -4.25319477 3 More
GO:0034367 protein-containing complex remodeling GO Biological Processes -22.5554593 16 More
GO:0034368 protein-lipid complex remodeling GO Biological Processes -23.1924108 16 More
GO:0034369 plasma lipoprotein particle remodeling GO Biological Processes -23.1924108 16 More
GO:0034374 low-density lipoprotein particle remodeling GO Biological Processes -13.3517229 9 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044060 regulation of endocrine process GO Biological Processes -7.84992769 12 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0045834 positive regulation of lipid metabolic process GO Biological Processes -24.1838255 28 More
GO:0045940 positive regulation of steroid metabolic process GO Biological Processes -11.4541194 10 More
GO:0046883 regulation of hormone secretion GO Biological Processes -20.4338227 29 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051341 regulation of oxidoreductase activity GO Biological Processes -18.1249013 32 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051353 positive regulation of oxidoreductase activity GO Biological Processes -12.6682372 20 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0060191 regulation of lipase activity GO Biological Processes -10.2745708 13 More
GO:0060193 positive regulation of lipase activity GO Biological Processes -9.32996784 11 More
GO:0071375 cellular response to peptide hormone stimulus GO Biological Processes -15.9961580 44 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071825 protein-lipid complex subunit organization GO Biological Processes -20.9970896 17 More
GO:0071827 plasma lipoprotein particle organization GO Biological Processes -21.6197515 17 More
GO:0072001 renal system development GO Biological Processes -17.7796243 52 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0097006 regulation of plasma lipoprotein particle levels GO Biological Processes -27.6960426 22 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:0098801 regulation of renal system process GO Biological Processes -10.5008143 14 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1904385 cellular response to angiotensin GO Biological Processes -6.40916397 6 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1990776 response to angiotensin GO Biological Processes -9.91352700 13 More
GO:2000377 regulation of reactive oxygen species metabolic process GO Biological Processes -19.1025541 38 More
KEGG pathways: 15 records
KEGG Description Category LogP Number of genes Detail
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04022 cGMP-PKG signaling pathway KEGG Pathway -9.74555098 16 More
hsa04072 Phospholipase D signaling pathway KEGG Pathway -3.77257282 17 More
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04261 Adrenergic signaling in cardiomyocytes KEGG Pathway -3.35554526 8 More
hsa04270 Vascular smooth muscle contraction KEGG Pathway -11.6218936 17 More
hsa04371 Apelin signaling pathway KEGG Pathway -6.49715749 12 More
hsa04614 Renin-angiotensin system KEGG Pathway -6.64459385 6 More
hsa04924 Renin secretion KEGG Pathway -9.25913478 11 More
hsa04925 Aldosterone synthesis and secretion KEGG Pathway -3.76850718 7 More
hsa04927 Cortisol synthesis and secretion KEGG Pathway -2.97866114 5 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa04934 Cushing syndrome KEGG Pathway -3.26102406 8 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05415 Diabetic cardiomyopathy KEGG Pathway -11.4800633 20 More
Drug-Gene interaction
view
Related drugs: 49 records
Drug name Interaction type Source PMID View
androstanolone NCI 1699048916482568 view
atorvastatin NCIPharmGKB 11179461 view
azilsartan antagonist TdgClinicalTrialChemblInteractionsTTD view
azilsartan kamedoxomil antagonist ChemblInteractions view
azilsartan medoxomil TTD view
candesartan antagonist TdgClinicalTrialTENDPharmGKBTTD 10826401175883001096819916901636194366501956327511752352185940501250478110805052166015699892163 view
candesartan cilexetil antagonist ChemblInteractions view
captopril PharmGKB 19286758 view
chembl125044 DTC view
chembl1390716 DTC view
chembl1445650 DTC view
chembl1492017 DTC view
chembl1972216 DTC view
chembl2094484 DTC view
chembl261693 DTC view
chembl347610 TTD view
chembl400912 DTC view
chembl421088 DTC view
chembl528694 DTC view
chembl586135 DTC view
chembl591834 DTC view
cl-329167 TTD view
cyclosporine NCI 17477024 view
dexamethasone NCI 16482568 view
disulfiram DTC view
eprosartan antagonist TdgClinicalTrialTENDTTD 127821931254052012517247127663891809340711752352129272261218406211320369108567329602957 view
eprosartan mesylate antagonist ChemblInteractions view
forasartan antagonist TdgClinicalTrialTENDTTD 898106591563521156961111752352 view
genistein NCI 7476882 view
helenalin DTC view
idoxifene NCI 11588112 view
indomethacin NCI 9357777 view
irbesartan antagonist TdgClinicalTrialChemblInteractionsTENDTTD 7843749103732241082221015101793147162051862721211752352100696821007538111486244150302941740861310082498 view
levodopa NCI 9458818 view
losartan antagonist DTCTdgClinicalTrialTENDPharmGKBTTD 12719755159919371271052916509571157433631059479320436376150268751175235215573751 view
losartan potassium antagonist ChemblInteractions view
nitrendipine PharmGKB 8952600 view
olmesartan antagonist TdgClinicalTrialChemblInteractionsTEND 171632321145121216220064117523521677550912076183 view
olmesartan medoxomil antagonist ChemblInteractions view
perindopril PharmGKB 207125298952600 view
pratosartan antagonist ChemblInteractionsTTD view
saprisartan antagonist TdgClinicalTrialTENDTTD 1057974911752352 view
saralasin TTD view
saralasin acetate antagonist ChemblInteractions view
sparsentan antagonist ChemblInteractionsTTD view
tasosartan antagonist TdgClinicalTrialTENDTTD 11683476121138201175235211046101 view
telmisartan antagonist TdgClinicalTrialChemblInteractionsTENDTTD 98789911140852615617852191476801155883516938288154985861006780011444497204487979259062117523521769196118580862 view
valsartan antagonist TdgClinicalTrialChemblInteractionsTENDTTD 8242249124607058577935155795161202368611752352 view
volanesorsen sodium NCI 10100098 view
Related studies: 25 records
Molecular factor Omics type Application Objective MI type Reference
NM_000685.5:c.-810T>A genomics myocardial infarction[diagnosis] myocardial infarction Poirier O et al. J Hypertens. 1998
NM_000685.5:c.573C>T genomics myocardial infarction[diagnosis] myocardial infarction Schelleman H et al. Pharmacogenomics J. 2008
NM_000685.5:c.573C>T genomics myocardial infarction[diagnosis] myocardial infarction Morales-Suarez-Varela MM et al. Cardiovasc Pathol. 2011
NM_000685.5:c.[-1106A>T;-48+59A>G;-47-11020G>A;573C>T;*86A>C;*798G>A] genomics myocardial infarction[diagnosis] myocardial infarction Su S et al. Pharmacogenetics. 2004
type-1 angiotensin II receptor proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Li SM et al. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997
type-1 angiotensin II receptor proteomics puerarin[treatment (pharmacotherapy)] acute myocardial infarction Li SM et al. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997
type-1 angiotensin II receptor proteomics left ventricular remodeling[prognosis (bad)] acute myocardial infarction Maczewski M et al. Eur J Heart Fail. 2006
NM_000685.5:c.*86A>C genomics myocardial infarction[diagnosis] myocardial infarction Berge KE et al. Clin Genet. 1997
NM_000685.5:c.*86A>C genomics myocardial infarction[diagnosis] myocardial infarction Fernandez-Arcas N et al. Atherosclerosis. 1999
NM_000685.5:c.*86A>C genomics myocardial infarction[diagnosis] myocardial infarction Fatini C et al. Eur Heart J. 2000
NM_000685.5:c.*86A>C genomics myocardial infarction[diagnosis] myocardial infarction Canavy I et al. Thromb Haemost. 2000
NM_000685.5:c.*86A>C genomics myocardial infarction[diagnosis] myocardial infarction Chistiakov DA et al. Ter Arkh. 2000
NM_000685.5:c.*86A>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Aoki S et al. Jpn Heart J. 2001
NM_000685.5:c.*86A>C genomics blood flow velocity[other] acute anterior myocardial infarction Ozturk O et al. Echocardiography. 2006
NM_000685.5:c.*86A>C genomics adverse events[prognosis (bad)] acute myocardial infarction Franco E et al. BMC Med Genet. 2007
NM_000685.5:c.*86A>C genomics cardiovascular death[prognosis (bad)] acute myocardial infarction Filippi-Codaccioni E et al. EuroIntervention. 2005
NM_000685.5:c.*86A>C genomics death[prognosis (bad)] acute myocardial infarction Filippi-Codaccioni E et al. EuroIntervention. 2005
NM_000685.5:c.*86A>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Mehri S et al. J Renin Angiotensin Aldosterone Syst. 2011
NM_000685.5:c.*86A>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Kaur R et al. J Renin Angiotensin Aldosterone Syst. 2012
NM_000685.5:c.*86A>C genomics myocardial infarction[diagnosis] myocardial infarction Kruzliak P et al. Dis Markers. 2013
NM_000685.5:c.*86A>C genomics sudden cardiac death[prognosis (bad)] myocardial infarction Kruzliak P et al. Dis Markers. 2013
NM_000685.5:c.*86A>C genomics left anterior descending artery culprit lesion[other] myocardial infarction Kruzliak P et al. Dis Markers. 2013
NM_000685.5:c.*86A>C genomics T-peak to T-end interval[other] acute anterior myocardial infarction Ozturk O et al. Korean Circ J. 2016
NM_000685.5:c.*86A>C genomics myocardial infarction[diagnosis] myocardial infarction Tiret L et al. Lancet. 1994
type-1 angiotensin II receptor proteomics left ventricular systolic dysfunction[prognosis (bad)] acute myocardial infarction Maczewski M et al. Int J Cardiol. 2008
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